Department of Psychological Sciences, Purdue University

Purdue Institute for Integrative Neuroscience

making memories since 2014

Neurons in the infralimbic region of the prefrontal cortex specifically projecting to the basolateral amygdala expressing inhibitory DREADD receptors tagged with mCherry

Sangha Lab 

razzle dazzle provided by M. Pollock

Science can be hard. It's important to have fun.

What we do


Clinical disorders arising from maladaptive emotion regulation present a large burden on society worldwide and many of these disorders show comorbidity, for example, addiction with anxiety disorders. Even though there has been much research on reward and fear processing, the majority of studies have been conducted in parallel, investigating the neuronal circuitries separately. Our lab uses a behavioral paradigm designed to assess how safety cues can regulate fear and reward seeking behaviors in rats. We hope by investigating how safety, fear and reward circuits integrate their functions to influence behavior, we will be able to better understand and treat disorders resulting from maladaptive emotion regulation.  

Susan Sangha, PhD

Assistant Professor of Neuroscience

Department of Psychological Sciences

Purdue Institute for Integrative Neuroscience

Dr. Susan Sangha receives a 2018 Seed for Success Award for Research in Excellence by Purdue University. See a short video clip about Dr. Sangha's award here

Newest publications from the lab:

Sangha S, Diehl MM, Bergstrom HC, Drew MR (2019). Know Safety, No Fear. Neuroscience & Biobehavioral Reviews, in press.

Greiner EM, Müller I, Norris MR, Ng KH, Sangha S (2019). Sex differences in fear regulation and reward seeking behaviors in a fear-safety-reward discrimination task. Behavioral Brain Research 368: 111903

Müller I, Brinkman AL, Sowinski EM, Sangha S (2018). Adolescent conditioning affects rate of adult fear, safety and reward learning during discriminative conditioning. Scientific Reports 8:17315

Sangha S and Foti D (2018). Neurobiology of Abnormal Emotion and Motivated Behaviors: Integrating Animal and Human Research. 1st edition. Cambridge, Massachusetts: Academic Press.

Ng K, Pollock MW, Urbanczyk PJ, Sangha S (2018). Altering D1 receptor activity in the basolateral amygdala impairs fear suppression during a safety cue. Neurobiology of Learning & Memory 147: 26-34