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Sangha Lab 

What we do

 

Clinical disorders arising from maladaptive emotion regulation present a large burden on society worldwide and many of these disorders show comorbidity, for example, addiction with anxiety disorders. Even though there has been much research on reward and fear processing, the majority of studies have been conducted in parallel, investigating the neuronal circuitries separately. Our lab uses a behavioral paradigm designed to assess how safety cues can regulate fear and reward seeking behaviors in male and female rats. We hope by investigating how safety, fear and reward circuits integrate their functions to influence behavior, we will be able to better understand and treat disorders resulting from maladaptive emotion regulation.  

razzle dazzle provided by M. Pollock

Department of Psychiatry, Indiana University School of Medicine

Stark Neuroscience Research Institute

Susan Sangha, PhD

Associate Professor of Psychiatry

Indiana University School of Medicine

Stark Neuroscience Research Institute

​​Newest publications from the lab:​

Ng K, Sangha S (2022). Encoding of conditioned inhibitors of fear in the infralimbic cortex. Cerebral Cortex, https://doi.org/10.1093/cercor/bhac450.


Hackleman A, Ibrahim M, Shim K, Sangha S (2022). Interaction of stress and alcohol on discriminating fear from safety and reward in male and female rats. Psychopharmacology, https://doi.org/10.1007/s00213-022-06206-5.


Sangha S (2021). Elevated dopamine in the amygdala disrupts infant's approach to mother: Implications for development of neurotypical social behaviors and networks. Neuron 109: 3900-3902


Meyer HC, Sangha S, Radley JJ, LaLumiere RT, Baratta MV (2021). Environmental certainty influences the neural systems regulating responses to threat and stress. Neuroscience and Biobehavioral Reviews 131: 1037-1055


Müller I, Adams DD, Sangha S, Chester JA (2021). Juvenile stress facilitates safety learning in male and female high alcohol preferring mice. Behavioural Brain Research 400: 113006


Krueger JN, Sangha S (2021). On the basis of sex: Differences in safety discrimination vs. conditioned inhibition. Behavioural Brain Research 400: 113024